Transcriptional programming of adipose tissue macrophages during metaflammation (P16)

• Subject Area: Immunology ; General Genetics and Functional Genome Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Macrophages are import mediators of low-level inflammation associated with metabolic diseases. During metaflammation, proinflammatory cytokines and mediators act on tissue-resident macrophages and recruited monocytes resulting in transcriptional reprogramming towards a pro-inflammatory state. This project aims to understand the programming of macrophages in metaflammation in visceral adipose tissue (VAT) on the single-cell level to identify transcription factors responsible for pro-inflammatory differentiation of VAT macrophages which could potentially serve as future therapeutic targets to limit metaflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Privatdozent Dr. Marc Beyer