NaCl-dependent functional differentiation of dermal myeloid cell subpopulations (P13)

• Subject Area: Immunology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

This project aims at identifying the physiologically significant myeloid populations, that respond to excess dietary salt (NaCl) in the skin. We will identify the underlying cellular dynamics and molecular mechanisms using flow cytometry, imaging, and transcriptomic analyses. Furthermore, we will analyse salt-modulated pathways in macrophages, which affect their ‘metaflammatory’ differentiation, their migratory dynamics and localization in the organ, as well as the triggering of hypersensitive reactions of the skin.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Waldemar Kolanus; Professorin Dr. Elvira Mass