NaCl-mediated programming of macrophage core functions (P13)

• Subject Area: Immunology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

We could show that elevated sodium levels perturb macrophage migration, phagocytosis, and efferocytosis. However, the precise signalling pathways influenced by sodium intake and the resulting impact on macrophage functions and overall organismal health remain elusive. We now aim to investigate the effects of high-salt diet (HSD) on organ-specific immunity, focusing on the gut-liver axis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Waldemar Kolanus; Professorin Dr. Elvira Mass