Proteomics identification of macrophage-derived signals impacting metaflammation in tissues (P11)

• Subject Area: Immunology ; Biochemistry
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Macrophage (MΦ)-derived signals regulate tissue homeostasis and drive pathophysiology in meta-flammation. Due to previous technical limitations in studying the intercellular signals comprehensively in vivo, however, few of these signals have been discovered and studied mechanistically. This projects aims to develop mass spectrometry-based proteomics methods, including cell-type specific labelling, to dissect the communication between MΦs, tissue-resident and infiltrating cells during high fat diet in vivo. We will generate a system-level view on tissue MΦ signals with a focus on the liver and provide the basis for new hypotheses to target Ms in order to attenuate or revert metaflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Felix Meissner