The impact of IL-1R1 expressing liver macrophages in the development of hepatic IL-6 resistance and its complications (P09)

• Subject Area: Immunology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

We found that hepatic IL-6 resistance provokes hepatic fibrosis and the development of insulin resistance via Csf1 that promotes accumulation/differentiation of monocyte-derived Cx3cR1-expressing macrophages. Inducible Csf1r inactivation in monocyte-derived macrophages ameliorated fibrosis and insulin resistance by abrogating macrophage polarization towards a fibrotic phenotype. We now aim to elucidate the cell type-specific functions of IL-1R1 signalling in the development of IL-6 resistance and fibrosis during obesity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Frank Thomas Wunderlich