Effects of maternal and early postnatal high-fat diet on the developmental programming of brain-resident macrophages
(P08)
Subject Area
Immunology
Developmental Biology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352
We have shown that maternal obesity exacerbates the development of fatty liver disease. This is attributed to the developmental programming of hepatic macrophages by maternal-derived metabolites, disrupting their core functions essential for tissue homeostasis. To investigate whether maternal metaflammation also affects other long-lived, tissue-resident macrophages during distinct developmental stages, we will now investigate the effects of maternal and early postnatal high-fat diet on the developmental programming of brain-resident macrophages.
DFG Programme
Collaborative Research Centres
