Single cell approaches to define cellular programming by environmental stimuli (P02)

• Subject Area: Immunology ; Clinical Immunology and Allergology ; Cell Biology
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

The immune system responds to many substances present in our environment as well as lifestyle factors such as lack of exercise or Western-type diets, that can trigger inadequate immune reactions leading to chronic low-grade inflammation. Using single cell omics (SCO) technologies, we aim to understand the (inter)cellular and molecular complexity during metaflammation by developing a whole blood-based compound incubation assay to identify compounds that induce metaflammation - prototypically tested for AhR ligands-, and by translating this assay into a clinical setting to assess individual reactivities to environmental metaflammation-driving compounds.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Dr. Anna Aschenbrenner; Professor Dr. Joachim L. Schultze