ATP Citrate Lyase (ACLY)-mediated macrophage reprogramming in metaflammation (P01)

• Subject Area: Immunology ; Endocrinology, Diabetology, Metabolism ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

This project focuses on the intricate relationship between adenosine triphosphate citrate lyase (ACLY) activity, respiratory metabolism, and the synthesis of key metabolites like aspartate (Asp), itaconate, metaconate, and nitric oxide (NO) in macrophages in the context metaflammation. They will study the interaction between macrophages and tissue cells, including adipocytes and endothelial cells, focusing on these metabolic pathways and metabolites in the context of obesity, hypertension, and inflammatory responses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Karsten Hiller; Professor Dr. Eicke Latz