ATP Citrate Lyase (ACLY)-mediated macrophage reprogramming in metaflammation (P01)

Subject Area Immunology
Endocrinology, Diabetology, Metabolism
Cell Biology
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352
 

Project Description

This project focuses on the intricate relationship between adenosine triphosphate citrate lyase (ACLY) activity, respiratory metabolism, and the synthesis of key metabolites like aspartate (Asp), itaconate, metaconate, and nitric oxide (NO) in macrophages in the context metaflammation. They will study the interaction between macrophages and tissue cells, including adipocytes and endothelial cells, focusing on these metabolic pathways and metabolites in the context of obesity, hypertension, and inflammatory responses.
DFG Programme Collaborative Research Centres
Subproject of SFB 1454:  Metaflammation and Cellular Programming
Applicant Institution Rheinische Friedrich-Wilhelms-Universität Bonn
Project Heads Professor Dr. Karsten Hiller; Professor Dr. Eicke Latz