Mobilizing reserve in episodic memory in individuals with Alzheimer`s disease pathology (B02)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this project we aim to uncover mechanisms that can enhance and mobilize the neurocognitive circuitry enabling precision in episodic memory. We will use anatomically focused transcranial ultrasound stimulation (TUS) of hippocampal-entorhinal circuitry versus cognitive reserve regions that we have identified in large cohort studies. We will perform these interventions in young individuals and older adults with amyloid pathology. We will also harness emerging anti-amyloid treatments to uncover how eliminating amyloid plaques impacts on synaptic function in neurocognitive circuits for memory precision, in regions serving cognitive reserve. Together, these work packages will provide causal insights which mechanisms can contribute to the mobilization of episodic memory circuitry in the face of pathology.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Radoslaw Martin Cichy; Professor Dr. Emrah Düzel