Unraveling Theta: Decoding Inhibitory Circuits in Alzheimer's Mouse-Human Research (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

Our mouse-human project aims to study how impairments in inhibitory microcircuits during theta states affect neural processing of environmental inputs, particularly in Alzheimer's disease models. The research will focus on different types of inhibitory circuit motifs and their impact on cognitive functions such as memory encoding and retrieval. By utilizing hAPP mouse models, researchers will investigate how beta-amyloidosis disrupts these circuits and contributes to memory deficits. We demonstrate to MCI patients how locomotion counteracts cognitive limitations. The study will also explore potential therapeutic targets related to inhibitory neuron function. Overall, this work package aims to uncover key neural mechanisms underlying cognitive impairment in Alzheimer's disease, with a specific focus on the role of inhibitory circuits during theta states.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Privatdozent Dr. Stefan Dürschmid; Professor Dr. Stefan Remy