Shaping neuronal engram ensembles through excitation-transcription coupling (A02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this project, we are investigating how transport of macromolecular protein complexes from synapse to nucleus regulate CREB-dependent gene expression and how this regulation relates to memory allocation and memory consolidation. We propose to harness excitation-transcription coupling via CREB as a neural resource to enhance memory formation. To this end, we will investigate how one can employ the signaling principles of the synapto-nuclear protein messenger Jacob as reserve to optimize neuronal engram ensemble formation in ageing and Alzheimer's disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Katarzyna Grochowska; Anna Karpova, Ph.D.; Dr. Michael R. Kreutz