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Shaping neuronal engram ensembles through excitation-transcription coupling (A02)

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996
 
In this project, we are investigating how transport of macromolecular protein complexes from synapse to nucleus regulate CREB-dependent gene expression and how this regulation relates to memory allocation and memory consolidation. We propose to harness excitation-transcription coupling via CREB as a neural resource to enhance memory formation. To this end, we will investigate how one can employ the signaling principles of the synapto-nuclear protein messenger Jacob as reserve to optimize neuronal engram ensemble formation in ageing and Alzheimer's disease.
DFG Programme Collaborative Research Centres
 
 

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