Plasmodium Escape from Protective Shells: Species- and Stage-Specific Functions of SERA Cysteine Proteases in Egress from Oocysts and Erythrocytes

• Applicant: Professor Dr. Kai Matuschewski
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 446480702

Malarial parasites follow a complex developmental program and have the remarkable capacity to develop inside protected shells. The exit out of red blood cells and cysts in the mosquito vector is unique amongst pathogenic microorganisms. A central role belongs to tailor-made proteases that are only made in Plasmodium and closely related blood parasites. In this project, the molecular mechanisms exerted by these proteins will be studied. Employing a murine malaria model and cultured human malaria parasites experimental genetics tools will introduce deletions, mutations and labelings into the parasite-encoded genes to permit in-depth microscopic and biochemical studies. The results of this work form a critical stepping stone towards innovative evidence-based strategies to hold parasites captive in their protective shells.

• DFG Programme: Priority Programmes
• Subproject of: SPP 2225: Exit strategies of intracellular pathogens