Advancing neurostimulation to personalized, symptom-related, adaptive stimulation: from chronic biomarker monitoring to clinical application beyond motor symptoms (C04)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

The project focuses on parameter optimization for adaptive deep brain stimulation (aDBS) in Parkinson’s disease (PD). First, we will expand on our results from the first funding period testing specific stimulation parameters for optimal beta burst suppression during aDBS and the role of cortical sensing sources (WP1). In WP 2, we will exploit the opportunity of chronic sensing to define stable biomarkers during real world conditions including high-resolution home monitoring based on wearable sensors and smartphone-questionnaires aiming to translate aDBS to clinical practice. Finally, WP3 will test non-motor symptoms in PD and obsessive-compulsive disorder in a cross-diagnostic approach to identify non-motor biomarkers during motivational and compulsion tasks.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• International Connection: Israel
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Renana Eitan; Professorin Dr. Andrea Kühn; Dr. Gerd Helge Schneider