Characterization and modulation of oscillatory bursting activity within the basal ganglia-thalamo-cortical network in PD (C01)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

In the first funding period, we identified cortical responses evoked by single-pulse stimulation of the subthalamic nucleus (STN). We established a relationship between these responses and clinical outcome, which could be utilized to determine optimal STN deep brain stimulation (DBS). Within the new funding period, this knowledge will be used to characterize the temporal dynamics of the basal-ganglia-thalamo-cortical activity to better understand the modulatory effects of STN-DBS on this network. Based on these insights, adaptive stimulation protocols will be developed to modulate abnormal dynamics and provide more efficient STN-DBS.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Esther Florin; Professor Dr. Alfons Schnitzler