Roles of the CNFY toxin for Yersinia pseudotuberculosis for crossing intestinal barriers, colonization of subepithelial tissue and pathology
(B12*)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2020 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
CNFY of Yersinia pseudotuberculosis is a key virulence factor that triggers the activation of Rho GTPases, which control cytoskeletal dynamics in phagocytes and contributes significantly to the induction of inflammatory responses and formation of necrosis in intestinal lymphoid tissues. The underlying mechanisms, however, are still unclear. We will therefore (i) analyze how the CNFY toxin modulates cell barrier functions and influences cellular penetration processes, and (ii) will characterize the influence of CNFY on targeted immune cells and the induction of inflammatory responses, phagocytosis and cell death. This will help us to evaluate potential host factors counteracting CNFY -triggered detrimental inflammatory responses and tissue destruction.
DFG Programme
Collaborative Research Centres
