Interaction of macrophages with cell matrix niches in lymphoid organs (A12*)

Subject Area Immunology
Term from 2020 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
 

Project Description

Lymphoid follicles within secondary lymphoid organs are anatomically delineated by biological barriers formed by specialized stromal endothelial cells. We previously observed that CD169+ macrophages interact with the stroma in these barriers. We aim to decode the molecular pathways defining these macrophage-stromal cell interactions and their impact in the specific immune responses to blood- and lymph-borne pathogens.
DFG Programme Collaborative Research Centres
Subproject of SFB 1009:  Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
Applicant Institution Universität Münster
Project Head Dr. Noelia Alonso Gonzalez