The immune-metabolic basis of the DEL-1/αvβ3 integrin-dependent induction of resolving macrophages in the resolution of inflammatory arthritis (C07*)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

The project (Chavakis) is a new project, which builds on very recent findings on the molecular nature of the pro-resolving effect of efferocytosis- the uptake of apoptotic neutrophils by macrophages. It is based on a new pathway in resolution of inflammation: The DEL-1/v3 integrin-dependent efferocytosis of apoptotic neutrophils by macrophages promotes the emergence of a pro-resolving macrophage phenotype. The project aims at understanding the cellular metabolic basis of the DEL-1/v3 integrin-dependent induction of pro-resolving macrophages in the context of resolution of inflammatory arthritis. The project additionally brings cell metabolism expertise.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Triantafyllos Chavakis