Macrophage lncRNAs in heart repair (B06)

• Subject Area: Cell Biology ; Cardiology, Angiology ; Pharmacology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

Cardiac resident macrophages (CRM) have a critical role in the orchestration of immune cell recruitment, wound healing, and cardiac function after myocardial injury. Our project will characterize conserved human long non-coding RNA (lncRNA) that were previously shown to influence murine macrophage function. Using established and novel human models such as cardiac tissue slices or organoids, we will explore CRM lncRNA mechanisms in cardiac injury and repair in vitro, ex vivo and in vivo.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Dr. Anne Dueck; Professor Dr. Stefan Engelhardt, until 6/2023; Professorin Alessandra Moretti, Ph.D., since 7/2023