Project Details
Projekt
Vascular lncRNAs in the control of the BRG1 remodeling complex (A04)
Subject Area
Anatomy and Physiology
Biochemistry
Biochemistry
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255
The project evaluates the importance of lncRNAs in the control of the BRG1 chromatin remodeling complex. In the past funding period, we identified BRG1-interacting lncRNAs and their importance for BRG1 genomic binding. We characterised two BRG1-interacting lncRNAs and reported their function in endothelial cells. In the next funding period, we will identify the general principle of the interaction of BRG1 with lncRNAs (i.e. phase separation vs. scaffolding function) and the functional consequences for the epigenetic control (histone positioning, 3D-chromatin structure) of endothelial gene expression and splicing.
DFG Programme
CRC/Transregios
Subproject of
TRR 267:
Non-coding RNA in the cardiovascular system
Applicant Institution
Technische Universität München (TUM)
Project Heads
Professor Dr. Ralf P. Brandes, until 6/2023; Dr. Matthias S. Leisegang
