Mex3a-dependent regulation of microRNAs in cardiac disease (A02)

• Subject Area: Cell Biology ; Cardiology, Angiology ; Structural Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

Besides the interaction of the RNA-binding protein Mex3a with miR-126-5p, which is instrumental in preserving endothelial integrity, its functional role remains unknown. We hypothesise that Mex3a may interact with other miRNAs in distinct cell types to affect trafficking and function. In this project, we aim to investigate mechanisms of miRNA selection, the functional relevance of their interaction with Mex3a, the structural basis of a ternary complex of Mex3a and AGO2 with miRNAs, and possible stabilising approaches. As Mex3a expression is stimulated by pathological cardiac stimuli, the contribution of Mex3a and interacting miRNAs to cardiac remodeling/function will be explored.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Michael Sattler; Professor Dr. Christian Weber