Elucidating protein-RNA interactions in circRNA biogenesis and function (A01)

• Subject Area: Cardiology, Angiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

Circular RNAs (circRNAs) are generated by backsplicing and are abundantly expressed in many human tissues, yet their contribution to physiology and disease remains largely unknown. The aim of this project is to identify and characterise circRNA biogenesis and functions in endothelial cells. Specifically, we will study the function and mechanism of action of the previously identified circRNA cZNF292 and elucidate the regulation of circRNA biogenesis by combining bioinformatics with biochemical approaches and physiological assays.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professorin Dr. Stefanie Dimmeler; Dr. Katharina Zarnack