MYC gene family members as modulators of tumorigenesis and druggable signaling pathways in SCLC (A02+)

• Subject Area: Cell Biology ; Hematology, Oncology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 413326622

In the project M. Sos will study the role of MYC paralog activation in SCLC, employing computational genomics, to generate profiles of genomic and epigenomic alterations that lead to MYC paralog activation. Furthermore CRISPRa/dCas9 based cellular SCLC models and pharmacological perturbation experiments will be used to identify individual MYC paralogs to evaluate their impact on differentiation in SCLC and druggable vulnerabilities in these Tumors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1399: Mechanisms of drug sensitivity and resistance in small cell lung cancer
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Martin Sos