SFB 1430:  Molecular Mechanisms of Cell State Transitions

• Subject Area: Biology ; Chemistry ; Medicine
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Molecular control of kinetochore-microtubule interactions at the metaphase-anaphase transition (Project Head Westermann, Stefan )
• A02 - Bridging the gap between cell biology and biochemistry with artificial protein prosthetics in cell cycle transitions (Project Head Musacchio, Andrea )
• A03 - VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control (Project Head Meyer, Hemmo )
• A04 - High-resolution electron microscopy of macro-molecular complexes in cell cycle regulation (Project Head Gatsogiannis, Christos )
• A05 - A molecular interface linking DNA replication with cell states of different replication Competence (Project Head Boos, Dominik )
• A06 - Implications of deregulated proteostasis in cell state transitions (Project Head Ehrmann, Michael )
• A07 - Golgi stress: impacting cell cycle transitions (Project Head Hellerschmied-Jelinek, Doris )
• A08 - Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions (Project Head Nalbant, Ph.D., Perihan )
• A09 - Targeting oncogene-induced DNA repair pathway switches (Project Head Reinhardt, Christian )
• A11 - Molecular regulation of differentiation and cell cycle in tumor-repopulating melanoma cells (Project Head Roesch, Alexander )
• A12 - Mechanisms of locally controlled JARID1B histone demethylase activity (Project Head Pöpsel, Simon )
• A13 - IFNy-induced cell state transition in melanoma (Project Head Paschen, Annette )
• A14 - Metastatic transition in pancreatic ductal adenocarcinoma (Project Head Grüner, Barbara )
• B01 - Developing chemical tools for investigating cell state transitions (Project Head Kaiser, Markus )
• B02 - Chemical tools to dissect roles of deubiquitinases in cell state transitions (Project Head Gersch, Malte )
• B03 - Development of selective inhibitors and PROTACs for key signalling molecules regulating cell state transitions and the cell cycle (Project Head Knapp, Stefan )
• B04 - Hybrid computational strategies for the study of cell states (Project Head Sanchez Garcia, Elsa )
• INF - Research data management (RDM)– an integrated database and standardised analysis of ex-perimental data (Project Heads Meyer, Hemmo ;  Rehwald, Stephanie ;  Schulze, Nina )
• MGKiRTG - Integrated Research Training Group on “Molecular and Chemical Cell Biology” (Project Heads Nalbant, Ph.D., Perihan ;  Westermann, Stefan )
• Z01 - Central Tasks of the Collaborative Research Centre (Project Head Meyer, Hemmo )
• Z02 - Detection and modulation of cell state transitions using advanced light microscopy (Project Head Schulze, Nina )
• Z03 - Central proteomics support (Project Head Kaschani, Farnusch )

• Applicant Institution: Universität Duisburg-Essen
• Spokesperson: Professor Dr. Hemmo Meyer