Project Details
Projekt
CKD and coagulation: dysregulation of the alternative complement pathway (C07)
Subject Area
Cardiology, Angiology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Patients with CKD display alterations in the coagulation system resulting in an increased thrombotic and bleeding risk, which causes an augmented cardiovascular risk in these patients. We recently demonstrated incorporation of complement C3 into fibrin clots, leading to a prothrombotic clot structure with thinner fibrin fibres and resistance to fibrinolysis. Recent findings raised the hypothesis that not only complement C3 itself but also complement activation may play an important role in prothrombotic clot alterations in CKD. This project will study the hypothesis that a dysregulation of the alternative complement pathway in CKD results in a prothrombotic phenotype and thereby increased cardiovascular risk in CKD patients.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Head
Privatdozentin Dr. Katharina Schütt
