The roles of Wnt signaling in genome stability (B03)

• Subject Area: Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

Our work demonstrated that autocrine Wnt signaling is required to maintain genome stability. Moreover, specific Wnts including Wnt10b play a key role in the regulation of DNA replication and mitosis. In addition, particular Wnt targets including the mitotic kinesin KIF2A directly regulate mitotic chromosome segregation. Based on this, we will explore how specific Wnt signals ensure genomic stability and we will investigate the biological significance of Wnt-dependent genome stability in self-renewing embryonic stem cells and in mouse embryonic development in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Sergio Pérez Acebrón; Professor Dr. Holger Bastians