Targeting radio- and chemo-resistance in metastatic phaeochromocytoma/ paraganglioma (B10)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Investigate neoadjuvant SSTR2-inducing treatments counteracting HIF2α-associated downregulation of SSTR2 to enhance [177Lu]Lu-DOTA-TATE therapy.(II) Establish and characterise irradiated co-culture models of MPC cells with tumour-associated macrophages with a focus on HIF2α activation, SDHB impairment, and COX-2 disruption.(III) Explore molecular characteristics of radiation-associated metastasis in disseminated MPC metastases models with HIF2α activation, SDHB impairment, and COX-2 disruption.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. Jens Pietzsch; Susan Richter, Ph.D.; Christian G. Ziegler, Ph.D.