Adrenal gland – crossroads of stress response – epigenetic, transcriptional, and metabolic analyses (A08)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

) Investigate epigenetic DNA and RNA modifications in adrenal tumour tissues leading to hypercortisolism.(II) Verify consequences of epigenetic DNA and RNA modifications on steroid hypersecretion in 3D cell cultures .(III) Study the impact of epigenetic DNA and RNA modifications on the adrenal metabolic microenviroment using MALDI-MSI.(IV) Establish functional consequences of epigenetic, transcriptional and metabolic regulations on plasma and urine steroid

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• International Connection: Israel
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. Alon Chen, until 6/2021; Dr. Anna Riester; Silviu Sbiera, Ph.D., since 7/2021