Development and context-dependent plasticity of brain macrophages (B07)

• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Biological Psychiatry
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Microglia and central nervous system (CNS)-associated macrophages (CAMs) are the key immune effector cells of the CNS. Microglia development strongly depends on colony stimulating factor 1 receptor (CSF1R) signaling. We aim to investigate at which stage of prenatal development and postnatal life the progenitors of microglia and CAMs differentially rely on CSF1R signaling using Csf1rdeltaFIRE/deltaFIRE mice. In a translational approach, we will study post-mortem brain tissue from humans with CSF1R-related leukencephalopathy. The results will provide a comprehensive characterization of the influence of age and microenvironment on CNS myeloid cells, and of their impact on neural cells throughout life.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Josef Priller; Professor Dr. Marco Prinz