Project Details
Projekt
How gut metabolites dictate CNS macrophages function in steady state, aging and neurodegeneration (A07)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Immunology
Immunology
Term
since 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
We showed previously that gut microbiota controls microglial maturation, function and metabolic state. We aim to decipher the Toll-like receptor (TLR)5-dependent as well as N(6)-Carboxymethyllysine (CML)-dependent mechanisms that regulate microglia and central nervous system (CNS)-associated macrophages (CAMs) in steady state, aging and neurodegeneration in preclinical mouse models and humans. We aim to identify novel gut metabolite-dependent molecular mechanisms that regulate the genetic and functional characteristics of CAMs and microglia in both, the healthy and pathologically aging CNS.
DFG Programme
CRC/Transregios
Subproject of
TRR 167:
Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution
Technische Universität München (TUM)
Project Heads
Privatdozent Dr. Thomas Blank; Professor Dr. Daniel Erny
