How the gut microbiota controls CNS macrophages during aging and age-related neurodegenerative diseases (A07)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

We propose to investigate the role of the microbiota in controlling the function of CNS-associatedmacrophages (CAMs), including meningeal (mMɸ), perivascular (pMɸ) and choroid plexusmacrophages (cpMɸ). Characteristics found during normal aging will be compared to the featuresfound during Alzheimer’s disease (AD). We will further determine the metabolic parameters in CAMsof specific pathogen-free (SPF) and germ-free (GF) mice during steady-state, aging and AD, anddetermine how their different special placement influences their phenotype and function.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Privatdozent Dr. Thomas Blank; Privatdozent Dr. Daniel Erny