Regulation of neural excitability and neural-network function in resilience - a multimodal and (back-) translational approach (B05)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264810226

Using neuronavigated transcranial magnetic stimulation over human dorsomedial prefrontal cortex (as a probe) in combination with simultaneous EEG (as a read-out), B05 will determine the excitability and cortico-cortical functional connectivity of this cortex area, pursuing the hypothesis that adaptive stress response during differential fear conditioning and excitability changes are linked to distinct functional cortical connectivity signatures and resilient outcome. Both, in mice and humans, B5 will conduct state-of-the-art functional connectivity measures, and a back-translation of human stimulus activation paradigms to the mouse. Finally, causal optogenetic manipulations will be developed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Sergiu Groppa; Professor Dr. Robert Nitsch, until 12/2016; Professor Dr. Albrecht Stroh; Professor Dr. Johannes Vogt, since 4/2019