SFB 1286:  Quantitative Synaptology

• Subject Area: Medicine ; Biology ; Physics
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - The ultrastructure of synapses in action (Project Head Cooper, Ph.D., Benjamin )
• A02 - Structure of synaptic organelles by X-ray diffraction and imaging (Project Head Salditt, Tim )
• A03 - A dynamic analysis of extracellular matrix (ECM) remodeling as a mechanism of synapse organization and plasticity (Project Head Rizzoli, Ph.D., Silvio-Olivier )
• A04 - Activity-dependent morphological changes at endbulb of Held synapses (Project Head Wichmann, Carolin )
• A05 - Mitochondrial heterogeneity in synapses (Project Head Jakobs, Stefan )
• A06 - Mitochondria function and turnover in synapses (Project Heads Rehling, Peter ;  Urlaub, Henning )
• A07 - The organization of the synaptic cytoskeleton (Project Heads D' Este, Elisa ;  Hell, Stefan W. )
• A08 - The role of post-translationally modified proteins in synaptic transmission (Project Heads Jahn, Reinhard ;  Urlaub, Henning )
• A09 - SUMOylation and Neddylation at Synapses (Project Heads Brose, Nils ;  Tirard, Marilyn )
• A11 - Molecular architecture of the presynaptic compartment (Project Head Lipstein-Thoms, Ph.D., Noa )
• A12 - Molecular organization of synaptic vesicles (Project Head Fernandez Busnadiego, Ruben )
• B02 - An in vitro approach to understanding the structure-organizing role of the vesicle cluster (Project Heads Köster, Sarah ;  Rizzoli, Ph.D., Silvio-Olivier )
• B04 - In vitro reconstitution of inhibitory GABAergic postsynapses (Project Head Steinem, Claudia )
• B05 - Quantitative molecular physiology of calyceal synapses (Project Head Moser, Tobias )
• B06 - The role of RNA in synapse physiology and neurodegeneration (Project Heads Fischer, André ;  Outeiro, Tiago Fleming )
• B08 - Defining cascades of molecular alterations in synucleinopathies during neurodegeneration (Project Head Outeiro, Tiago Fleming )
• B10 - Nanoscale Dynamics and Regulation of Synapsin Condensates (Project Head Milovanovic, Dragomir )
• B11 - Signaling mechanisms of synaptic state transitions in relation to long-term synaptic plasticity (Project Head Schlüter, Oliver M. )
• C01 - The plasticity-dependent spatiotemporal organization of AMPARs and scaffolding proteins (Project Head Tetzlaff, Christian )
• C02 - Release face designs and dynamics tailored for synaptic working memory (Project Head Wolf, Fred )
• C03 - Modelling dendritic spine fluctuations (Project Heads Fauth, Michael ;  Wörgötter, Florentin )
• C05 - The synapse as a complex physical environment (Project Head Klumpp, Stefan )
• C06 - Coarse-grained simulation of the role of local environment on presynaptic release: from fusion to fission (Project Head Müller, Marcus )
• C08 - Experimental and theoretical analysis of single active zone function (Project Head Moser, Tobias )
• C09 - Relating the presynaptic vesicle cycle to the information processing function of synaptic plasticity (Project Head Priesemann, Viola )
• C10 - Innovative deep learning approaches enable quantitative analyses of synaptic imaging datasets (Project Head Pape, Constantin )
• Z01 - Central Tasks (Project Head Rizzoli, Ph.D., Silvio-Olivier )
• Z02 - Integrative data analysis and interpretation, and generation of a synaptic integrative data strategy (SynIDs) (Project Head Bonn, Stefan )
• Z04 - Quantitative visualization and analysis of synaptic proteins using nanobodies (Project Head Opazo, Felipe )

Completed projects

• A10 - Protein–protein interactions at the synapse monitored by quantitative protein cross-linking (Project Head Urlaub, Henning )
• B01 - The organization of structural lipids in synaptic membranes (Project Head Phan, Thi Ngoc Nhu )
• B03 - Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging (Project Head Janshoff, Andreas )
• B09 - Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease (Project Head Lingor, Paul )
• Z03 - Simple multi-color super-resolution imaging by 10x expansion microscopy (Project Head Rizzoli, Ph.D., Silvio-Olivier )

• Applicant Institution: Georg-August-Universität Göttingen
• Spokesperson: Professor Silvio-Olivier Rizzoli, Ph.D.