TRR 205:  The Adrenal: Central Relay in Health and Disease

• Subject Area: Medicine ; Agriculture, Forestry and Veterinary Medicine ; Biology ; Chemistry
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

No abstract available

• DFG Programme: CRC/Transregios
• International Connection: France, Switzerland, United Kingdom

Current projects

• A01 - Regulated cell death in adrenal inflammation and septic shock (Project Heads Bornstein, Stefan R. ;  Kanczkowski, Waldemar ;  Linkermann, Andreas )
• A02 - The impact of hypoxia pathway proteins on the adrenergic response in the adrenal gland and beyond (Project Heads Chavakis, Triantafyllos ;  El-Armouche, Ali ;  Wielockx, Ph.D., Ben )
• A04 - In vitro and in vivo models of novel therapeutic approaches in congenital adrenal hyperplasia (Project Heads Hübner, Ph.D., Angela ;  Köhler, Katrin ;  Reisch, Nicole )
• A05 - Biological treatment of adrenal insufficiency by encapsulated xenogeneic adrenal cells (Project Heads Bornstein, Stefan R. ;  Ludwig, Barbara )
• A06 - Adrenal stem cells under homeostatic and stress conditions (Project Heads Andoniadou, Ph.D., Cynthia L. ;  Bornstein, Stefan R. ;  Schedl, Andreas ;  Steenblock, Charlotte )
• A07 - Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling (Project Heads Alexaki, Vasileia Ismini ;  Eaton, Suzanne ;  Henneicke, Ph.D., Holger )
• A08 - Adrenal gland – crossroads of stress response – epigenetic, transcriptional, and metabolic analyses (Project Heads Chen, Alon ;  Riester, Anna ;  Sbiera, Ph.D., Silviu )
• A09 - Sexual dimorphism of adrenal hormone action in metabolic tissues (Project Heads Herzig, Stephan ;  Uhlenhaut, Nina Henriette )
• B10 - Targeting radio- and chemo-resistance in metastatic phaeochromocytoma/ paraganglioma (Project Heads Pietzsch, Jens ;  Richter, Ph.D., Susan ;  Ziegler, Ph.D., Christian G. )
• B11 - The molecular pathology of PPGLs and genetically-driven molecular-targeted therapies: Towards precision medicine (Project Heads Nölting, Svenja ;  Pellegata, Natalia S. )
• B12 - HIF-MYC/MAX pathway in neural-crest derived catecholamine producing tumours: Identification of a metabolic fingerprint related to tumour aggressiveness (Project Heads Bechmann, Nicole ;  Eisenhofer, Ph.D., Graeme ;  Klink, Barbara ;  Lenders, Ph.D., Jacques W.M. )
• B13 - Genetic and environmental contributors to vascular function in primary aldosteronism (Project Heads Fuß, Carmina Teresa ;  Hahner, Stefanie ;  Reincke, Martin ;  Schirbel, Andreas )
• B14 - Identification and functional characterisation of genetic contributors to primary aldosteronism (Project Heads Beuschlein, Felix ;  Gudermann, Thomas ;  Reincke, Martin ;  Schneider, Holger )
• B15 - Pathophysiology and advanced approaches for subtyping in primary aldosteronism (Project Heads Eisenhofer, Ph.D., Graeme ;  Lenders, Ph.D., Jacques W.M. ;  Williams, Ph.D., Tracy Ann )
• B16 - Steroid hormones and cancer immunity – learning from adrenocortical carcinoma (Project Heads Fassnacht, Martin ;  Kroiß, Ph.D., Matthias )
• B17 - Molecular pathology and treatment of Cushing’s disease (Project Heads Reincke, Martin ;  Theodoropoulou, Marily )
• B19 - The physiology and pathophysiology of aldosterone production in the pig (Project Heads Kemter, Elisabeth Gabriele ;  Williams, Ph.D., Tracy Ann ;  Wolf, Eckhard )
• B20 - Targeting ferroptosis in adrenocortical carcinoma (ACC): from basic mechanisms to novel treatments (Project Heads Friedmann Angeli, José Pedro ;  Kroiß, Ph.D., Matthias ;  Weigand, Isabel )
• INF - Infrastructure for adrenal research (Project Heads Beuschlein, Felix ;  Eisenhofer, Ph.D., Graeme ;  Fassnacht, Martin ;  Müller-Pfefferkorn, Ralph ;  Reisch, Nicole )
• S01 - Analytical platform (Project Heads Alves, Tiago ;  Bidlingmaier, Martin ;  Kurlbaum, Max ;  Peitzsch, Mirko ;  Walch, Axel Karl )
• S02 - Patient cohorts and biobanks (Project Heads Eisenhofer, Ph.D., Graeme ;  Fassnacht, Martin ;  Pamporaki, Ph.D., Christina ;  Reincke, Martin )
• Z01 - Central Task (Project Head Bornstein, Stefan R. )

Completed projects

• A03 - Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model (Project Head Chavakis, Triantafyllos )

• Applicant Institution: Technische Universität Dresden
• Co-Applicant Institution: Julius-Maximilians-Universität Würzburg; Ludwig-Maximilians-Universität München
• Spokesperson: Professor Dr. Stefan R. Bornstein