Project Details
Projekt
FOR 832: Regulators of the Humoral Immune Response
Subject Area
Medicine
Term
from 2007 to 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 31394370
Since the discovery of the antibody-mediated (humoral) immune response more than 100 years ago, the structure of antibody molecules, the mechanisms for the generation of antibody diversity and for the secretion of antibodies have been elucidated. The regulation of the humoral immune response is not yet understood, however. In particular, the processes involved in the selection of the primary antibody repertoire and the negative selection of autoreactive B-lymphocytes, the intracellular signalling cascades during an immune response, the interaction of B-lymphocytes with other immune cells and the regulation of the lifespan of the plasma cells are only poorly understood. Therefore, this Research Unit is analysing the "Regulators of the humoral immune response".
In close cooperation eight research projects explore the molecular circuits that are involved in the regulation of B-lymphocytes. All projects use genetically engineered mouse models for the exploration of the humoral immune response in vivo. In addition, new mouse lines are developed in the projects. With this research programme we also hope to contribute for a better understanding of diseases, in which the humoral immune response has become deranged and disregulated like in autoimmune diseases, allergy and immune-deficiencies.
The participating institutes of the Research Unit are affiliated at the Natural Science Faculty and the University Hospital. The close interaction of the scientists in the monthly "B-Cell Club", invited seminar speakers as well as a coordinated programme for PhD students help to ensure the achievement of our scientific aims.
In close cooperation eight research projects explore the molecular circuits that are involved in the regulation of B-lymphocytes. All projects use genetically engineered mouse models for the exploration of the humoral immune response in vivo. In addition, new mouse lines are developed in the projects. With this research programme we also hope to contribute for a better understanding of diseases, in which the humoral immune response has become deranged and disregulated like in autoimmune diseases, allergy and immune-deficiencies.
The participating institutes of the Research Unit are affiliated at the Natural Science Faculty and the University Hospital. The close interaction of the scientists in the monthly "B-Cell Club", invited seminar speakers as well as a coordinated programme for PhD students help to ensure the achievement of our scientific aims.
DFG Programme
Research Units
Projects
- Einfluss deregulierter oder funktionell inaktiver inhibitorischer Rezeptoren auf die Aufrechterhaltung der Toleranz im humoralen Immunsystem der humanisierten Maus (Applicant Nimmerjahn, Falk )
- Etablierung von Doxyzyklin-regulierbaren Mauslinien zur reversiblen Expression von Transgenen in B-lymphoiden Zellen (Applicant Berens, Christian )
- Funktion des Krüppel-like Faktors 2 (KLF2) in der B-Zell-Homöostase und humoralen Immunantwort (Applicant Jäck, Hans-Martin )
- Neue IL-4-Signaltransduktionswege bei der Proliferation und Differenzierung von B-Zellen (Applicant Gessner, Ph.D., André )
- Plasmazellen als therapeutischer Ansatzpunkt bei Antikörper-vermittelten Autoimmunerkrankungen (Applicant Voll, Reinhard )
- Regulation der allelen Exklusion in B-Lymphozyten Vorläuferzellen (Applicant Winkler, Thomas )
- Regulation der B-Zellaktivierung durch Swiprosin-1/EFhd2 (Applicant Mielenz, Dirk )
- Untersuchungen zur Rolle von CD22 und Siglec-G in der Regulation von B-Zell-Aktivierung und systemischer Autoimmunität (Applicant Nitschke, Lars )
- Zentrale Mittel und Koordinationsmittel (Applicant Winkler, Thomas )
Spokesperson
Professor Dr. Thomas Winkler
