Liver receptor homolog-1 (LHR-1) regulates inflammation-induced fibrotic tissue remodeling (C01)

• Subject Area: Rheumatology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project C01 (Distler) focuses on the role of mesenchymal tissue responses and has established in vitro and in vivo techniques to characterize fibroblast activation, matrix deposition and repair. Based on preliminary data the project will define the role of liver receptor homolog-1 (LRH-1) in inflammation-induced tissue repair and fibrosis. LRH-1 is induced by TGFβ and controlled by epigenetic mechanisms that allow its persistent overexpression. The overexpression of LRH-1 promotes fibroblast activation and tissue fibrosis. C01 is a key project for analyzing mesenchymal tissue responses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Jörg Hans Wilhelm Distler