Liver receptor homolog-1 (LHR-1) regulates inflammation-induced fibrotic tissue remodeling
(C01)
Subject Area
Rheumatology
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037
Project C01 (Distler) focuses on the role of mesenchymal tissue responses and has established in vitro and in vivo techniques to characterize fibroblast activation, matrix deposition and repair. Based on preliminary data the project will define the role of liver receptor homolog-1 (LRH-1) in inflammation-induced tissue repair and fibrosis. LRH-1 is induced by TGFβ and controlled by epigenetic mechanisms that allow its persistent overexpression. The overexpression of LRH-1 promotes fibroblast activation and tissue fibrosis. C01 is a key project for analyzing mesenchymal tissue responses.
DFG Programme
Collaborative Research Centres
