Deciphering Batf-dependent and independent inflammatory and regulatory T cell programs at mucosal surfaces (B05)

• Subject Area: Gastroenterology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project B05 (Hildner) is dedicated to study the role of the transcription factor Batf in T cells during resolution of inflammation. Based on the preliminary data obtained in the first funding period, Batf appears to influence the colonic pool of lamina propria (LP)-residing regulatory T cells (Tregs) as well as intra-epithelially located non-Treg CD4+ T cells. The project will now characterize the Batf-dependent regulation of LP and intra-epithelially resp. located CD4+ T lymphocyte subpopulations and how these subsets differentially impact the resolution of colitis in mice and men.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Kai Hildner