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Dual contribution of the spleen tyrosine kinase (SYK) to epidermolysis bullosa acquisita pathogenesis

Subject Area Dermatology
Term from 2014 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 263860107
 
Final Report Year 2018

Final Report Abstract

Collectively we were able to demonstrate that: • Sykb is one of the major hub-genes expressed in the skin of mice with experimental EBA; • pharmacological SYK blockade dose-dependently and almost completely impairs induction of experimental EBA in mice induced by transfer of anti-COL7 IgG; • induction of anti-COL7 IgG-induced EBA requires SYK expression on cells of the myeloid, but not lymphoid linage; • SYK inhibition ablates signaling events downstream of SYK in immune complexactivated neutrophils; • Plaur and Fpr1 are involved in the SYK signaling pathway; • SYK is differentially expressed in skin with pemphigoid disease (BP and EBA) when compared to healthy control skin.

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