Project Details
Projekt
Regulatory role of non-coding RNAs and their homeostasis by autophagy in the progression of atherosclerosis (B05)
Subject Area
Cardiology, Angiology
Term
since 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445
The crosstalk between autophagy and non-coding RNAs in atherosclerosis remains unclear. Bulk, single-cell, and spatial RNA sequencing of human atherosclerosis identified several deregulated ncRNAs with potential relevance in autophagy (Aim 1). Among them, HAND2-AS1 interacts with autophagy-related mediators. Its functional role in vascular disease progression will be investigated (Aim 2). Further, we will study autophagy-induced ncRNA regulation through advanced proteomic and transcriptomic approaches (Aim 3). The contribution to atherosclerosis of identified RNA-binding proteins (e.g., MEX3A) will finally be studied in transgenic mice models (Aim 4).
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Dr. Yvonne Döring, until 6/2018; Professor Dr. Lars Mägdefessel; Dr. Donato Santovito; Professor Dr. Oliver Söhnlein, until 6/2022
