Hyperglycemia-induced metabolic reprogramming drives neutrophil cytotoxicity in atherosclerosis (A06)

• Subject Area: Cardiology, Angiology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445

Hyperglycemia is among the most important risk factors for atherosclerosis and its complications. Using mouse models of atherosclerosis, we will link the release of neutrophil extracellular traps (NETs) with hyperglycemia-accelerated plaque destabilization. Mechanistically, we will focus on how hyperglycemia reprograms neutrophils and their progenitors and how hyperglycemia alters the ability if NETs to kill host cells. Finally, we will integrate this knowledge to generate innovative approaches to boycott NET-driven cell death in hyperglycemia.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Dr. Maik Drechsler, until 6/2018; Carlos Silvestre-Roig, Ph.D.; Professor Dr. Oliver Söhnlein