Interactions of chemokines with heterologous effectors in atherosclerosis (A02)

• Subject Area: Cardiology, Angiology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445

Chemokines form heteromeric complexes with other chemokines and with galectins. This alters the recruitment of different immune cells and atherosclerosis. We will develop a new TR-FRET-based method to measure and better understand heteromerization and use it to identify inhibitors against atherosclerosis. Besides, we will analyze the importance of the existence of secretory vesicles in platelets and leukocytes for chemokine heteromers in atherosclerosis using conditional Nbeal2-/- mice. Last, we will investigate the role of Gal-3 for atherosclerosis in the context of heteromerization with chemokines in conditional knockout mice.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Jürgen Bernhagen, since 7/2022; Professor Dr. Hans-Joachim Gabius, until 8/2021 (†); Privatdozent Dr. Philipp von Hundelshausen; Professor Rory R. Koenen, Ph.D., until 6/2018