Functional characterization of the TRPP2 channel complex (P03)

• Subject Area: Anatomy and Physiology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

Mutations in transient receptor potential channel polycystin-2 (TRPP2) cause autosomal dominant polycystic kidney disease (ADPKD). TRPP2 is a Ca2+-permeable non-selective cation channel, but it is not known how TRPP2 channel activity translates into morphogenetic programs. We hypothesize that local Ca2+ signals are critical to regulate specific downstream factors in TRPP2 signaling micro-domains. We have identified novel proteins in the native TRPP2 complex which have revealed a putative mechanism of TRPP2-mediated cell shape regulation. The goal of this project is to investigate the function of proteins constituting the native TRPP2 complex in order to understand the role of TRPP2-mediated signaling in health and disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Michael Köttgen