Eine neue multimodale molekulare Bildgebungstechnik in der Hirntumorchirurgie: Nanopartikel-gestützte Raman-Spektroskopie und multispektrale optoakustische Tomographie zur Resektionsoptimierung maligner Gliome.

• Antragsteller: Privatdozent Dr. Volker Neuschmelting
• Fachliche Zuordnung: Klinische Neurologie; Neurochirurgie und Neuroradiologie
• Förderung: Förderung von 2014 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 259088719

• Erstellungsjahr: 2018

Zusammenfassung der Projektergebnisse

This study demonstrated the feasibility of MSOT to monitor the treatment effects of the emerging ablation techniques like photodynamic therapy by resolving the reduction of oxygen saturation in time and space. It also revealed another unknown potential of optoacoustics, namely its use in a theranostic approach in which a nano-second pulsed laser induces not only the diagnostic images but also serves as the inductor for activating the photosensitizer at the same time.

Projektbezogene Publikationen (Auswahl)

• (2018) Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation. Small (Weinheim an der Bergstrasse, Germany) 14 (23) e1800740
  Neuschmelting, Volker; Harmsen, Stefan; Beziere, Nicolas; Lockau, Hannah; Hsu, Hsiao-Ting; Huang, Ruimin; Razansky, Daniel; Ntziachristos, Vasilis; Kircher, Moritz F.
  
• Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles. ACS Nano 2016, 10, 5015–5026
  Andreou, C.; Neuschmelting, V.; Tschaharganeh, D.-F.; Huang, C.-H.; Oseledchyk, A.; Iacono, P.; Karabeber, H.; Colen, R. R.; Mannelli, L.; Lowe, S. W.; et al.
  
• Lymph Node Micrometastases and In-Transit Metastases from Melanoma : In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model. Radiology 2016, 280, 137–150
  Neuschmelting, V.; Lockau, H.; Ntziachristos, V.; Grimm, J.; Kircher, M. F.
  
• Performance of a Multispectral Optoacoustic Tomography (MSOT) System Equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation. Photoacoustics 2016, 4, 1–10
  Neuschmelting, V.; Burton, N. C.; Lockau, H.; Urich, A.; Harmsen, S.; Ntziachristos, V.; Kircher, M. F.
  
• WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice. Theranostics 2018, 8, 723–734
  Neuschmelting, V.; Kim, K.; Malekzadeh-Najafabadi, J.; Jebiwott, S.; Prakash, J.; Scherz, A.; Coleman, J. A.; Kircher, M. F.; Ntziachristos, V.