Carbazo-anilines: Enantioselective cross-dehydrogenative amination reactions for the preparation of unsymmetrical chiral diamines molecules, and their applications as enantiopure ligands

• Applicant: Professor Dr. Frederic W. Patureau
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 257130133

Carbazo-anilines: The general objective of this proposal is to investigate different pathways to access axially chiral enantiopure ortho-carbazo-anilines and to evaluate the potential of these compounds as chiral ligands. The main objective is to devise an enantioselective method in order to directly access enantio-enriched C-N cross-coupled products. This technology would be derived from the original racemic method that we have recently communicated, through C-N bond forming Cross-Dehydrogentive-Coupling. This project is innovative because we study here an unprecedented type of axial chirality, which is surprisingly not based on sterics, but on a unique intra-molecular NH-N H-bond.

• DFG Programme: Research Grants