Interplay of cell adhesion and matrix proteolysis in barrier-braking invadopodia of tumor cells
(A09)
Subject Area
Anatomy and Physiology
Term
from 2014 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
Cell adhesion to the extracellular matrix and its proteolysis by matrix metalloproteinases (MMPs) are essential to metastasis. In cancer cells, fibrillar type I collagen and presumably newly synthesized VE cadherin promote surface expression of MMP14, which can be measured with a FRET probe. Both ways of stimulating MMP14 will be studied in detail, particularly with regard to the supramolecular orientation of collagen fibrils and the cadherin switch typical of cancer cells. Translationally, MMP14 will be investigated for its potential to activate cancer-selective endocytosis of drugs in metastatic and vessel-integrated cancer cells.
DFG Programme
Collaborative Research Centres
