Interleukin-22 und Regeneration der Niere

• Antragsteller: Professor Dr. Hans-Joachim Anders
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 2014 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 252090668

• Erstellungsjahr: 2018

Zusammenfassung der Projektergebnisse

The project turned out to be quite successful in terms of generating new and in part unexpected insights in the biology of IL-22 in the kidney. To my best knowledge, we were the only ones in the world working on this topic and could come up with a bunch of new concepts following our initial paper published in J Am Soc Nephrol on IL-22 in acute kidney injury. We explored kidney regeneration, chronic progressive kidney atrophy, and renal cancer, just to name a few. As the most exciting result we identified IL-22R expression as a prognostic biomarker for clear cell RCC and raised a rationale also for using IL-22 blockade as a sensitizer for cytotoxic therapies. If there is a role for this in the current phase of check point inhibitors remains to be seen.

Projektbezogene Publikationen (Auswahl)

• Interleukin-22 in kidney injury and regeneration. Am J Physiol Renal Physiol. 2015 May 15;308(10):F1041-6
  Weidenbusch M, Rodler S, Anders HJ
  (Siehe online unter https://doi.org/10.1152/ajprenal.00005.2015)
• Links between coagulation, inflammation, regeneration, and fibrosis in kidney pathology. Lab Invest. 2016 Apr; 96(4):378-90.2015.164
  Suárez-Álvarez B, Liapis H, Anders HJ
  (Siehe online unter https://doi.org/10.1038/labinvest.2015.164)
• Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease. J Am Soc Nephrol. 2016 Sep;27(9):2564-75
  Anders HJ
  (Siehe online unter https://doi.org/10.1681/ASN.2016020177)
• Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep. 2016 Dec 9;36(6)
  Honarpisheh M, Desai J, Marschner JA, Weidenbusch M, Lech M, Vielhauer V, Anders HJ, Mulay SR
  (Siehe online unter https://doi.org/10.1042/BSR20160336)
• The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation? Mediators Inflamm. 2016;2016:2856213
  Kulkarni OP, Lichtnekert J, Anders HJ, Mulay SR
  (Siehe online unter https://doi.org/10.1155/2016/2856213)
• Evolutionary trade-offs in kidney injury and repair. Histol Histopathol 2017, May 8; 11900
  Lei Y, Anders HJ
  (Siehe online unter https://doi.org/10.14670/HH-11-900)
• Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury. Biosci Rep. 2017 Dec 22;37(6)
  Weidenbusch M, Rodler S, Song S, Romoli S, Marschner JA, Kraft F, Holderied A, Kumar S, Mulay SR, Honarpisheh M, Kumar Devarapu S, Lech M, Anders HJ
  (Siehe online unter https://doi.org/10.1042/BSR20170099)
• Thrombospondin immune regulation and the kidney. Nephrol Dial Transplant. 2017 Jan 14
  Ponticelli C, Anders HJ
  (Siehe online unter https://doi.org/10.1093/ndt/gfw431)
• Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury. Nat Commun. 2018 Apr 9;9(1):1344
  Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzinghi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasagni L, Romagnani P
  (Siehe online unter https://doi.org/10.1038/s41467-018-03753-4)
• IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis. Physiol Rep. 2018
  Weidenbusch M, Song, S, Iwakura T, Shi C, Rodler S, Kobold S, Mulay SR, Honarpisheh MM, Anders HJ
  (Siehe online unter https://doi.org/10.14814/phy2.13817)
• Necroptosis in Acute Kidney Injury. Nephron. 2018;139(4):342-348
  Anders HJ
  (Siehe online unter https://doi.org/10.1159/000489940)