Circadian clocks and hedonic appetite regulation (B01)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 222193485

This project analyses the mechanisms of circadian regulation of homeostatic and reward systems in the context of appetite regulation. We hypothesize that mesolimbic and hypothalamic circadian clocks coordinate hedonic and homeostatic control aspects of appetite regulation and food uptake, respectively. Using genetic and pharmacologic manipulations in mice and human studies, we will analyse the interplay between local clock control at the level of central appetite circuits and systemic circadian endocrine signals such as glucocorticoids and metabolic peptides.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 134: Ingestive Behaviour: Homeostasis and Reward
• Applicant Institution: Universität zu Lübeck
• Project Heads: Professor Dr. Sebastian Michael Meyhöfer; Professor Dr. Henrik Oster