Synaptic microcircuitry during axon regeneration: The role of rehabilitation in modulating neuronal tracts and behavioral outcomes following microtubule stabilisation treatment (A04)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

This project will continue to address mechanisms of axonal regeneration in the CNS, using spinal cord injury as a model. The project has shown already that systemic administration of the microtubule stabilizing drugs epothilone B and epothilone D induces axon regeneration and functional recovery after a spinal cord injury. The project will now elucidate how intense rehabilitation protocols affect both regeneration of synaptic micronetworks and behavioral recovery, the latter using high-precision behavioral readouts.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Frank Bradke; Dr. Jarred Griffin