Project Details
Projekt
Causal relations among system states and behavior in primate memory: a tACS perturbation approach
Applicants
Professor Dr. Nikos K. Logothetis; Professor Dr. Klaus Obermayer; Professor Dr. Walter Paulus
Subject Area
Cognitive, Systems and Behavioural Neurobiology
Human Cognitive and Systems Neuroscience
Human Cognitive and Systems Neuroscience
Term
from 2013 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 239068588
The main underlying premise of the proposed troika collaboration assumes a strong impact of oscillatory signals on memory processing in networks of cortical areas. The purpose of the proposed project is to experimentally manipulate properties of cortical oscillations, like their relative phase at different sites or their frequency dynamics, by transcranial alternating current stimulation. Hereby we will establish a causal relation between neuronal interactions across brain structures, information processing and cognitive memory performance, which should ultimately be manipulated in predictable ways. Parallel experiments in behaving human and non-human primates will advance the development and validation of a new multichannel stimulus generation for targeting deep brain structures like the hippocampus. Analysis of the oscillatory dynamics of cortico-subcortico-cortical networks will model and verify the new knowledge and allow for iterative generation of new hypotheses. The results of this project should provide important insights into memory processes that could be used during a second funding period to be applied in patients with memory deficits and a non-human primate model of Alzheimer disease with respective memory deficits.
DFG Programme
Priority Programmes
