Targeted delivery of drugs into adipocytes by peptide-mediated shuttling in a new obesity mouse model (B04)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

Based on own findings, we aim to selectively transport Tamoxifen (Tam) into adipocytes of our new spontaneous leptin receptor mutated mouse model using a peptide-mediated delivery system. We will set-up a system for fat cell specific Tamoxifen targeting using neuropeptide Y1Receptor. We want to elucidate and dissect the molecular mechanisms of Tam in AT during obesity development to identify an alternative therapeutic strategy at clinical level.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professorin Dr. Annette G. Beck-Sickinger; Privatdozentin Dr. Nora Klöting-Blüher